Towards the total synthesis of apicularen A
This thesis involves the synthesis of an intermediate towards Apicularen A utilizing indium-mediated conjugate addition of a thioester derived ketene to a conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential for its bioactivity as a potential anti-cancer agent.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/41762 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| id |
sg-ntu-dr.10356-41762 |
|---|---|
| record_format |
dspace |
| spelling |
sg-ntu-dr.10356-417622023-02-28T23:47:38Z Towards the total synthesis of apicularen A Chan, Jocelyn Li Ting Loh Teck Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis This thesis involves the synthesis of an intermediate towards Apicularen A utilizing indium-mediated conjugate addition of a thioester derived ketene to a conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential for its bioactivity as a potential anti-cancer agent. Master of Science 2010-08-11T07:10:47Z 2010-08-11T07:10:47Z 2008 2008 Thesis http://hdl.handle.net/10356/41762 en 74 p. application/pdf |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| continent |
Asia |
| country |
Singapore Singapore |
| content_provider |
NTU Library |
| collection |
DR-NTU |
| language |
English |
| topic |
DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis |
| spellingShingle |
DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis Chan, Jocelyn Li Ting Towards the total synthesis of apicularen A |
| description |
This thesis involves the synthesis of an intermediate towards Apicularen A
utilizing indium-mediated conjugate addition of a thioester derived ketene to a
conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential
for its bioactivity as a potential anti-cancer agent. |
| author2 |
Loh Teck Peng |
| author_facet |
Loh Teck Peng Chan, Jocelyn Li Ting |
| format |
Theses and Dissertations |
| author |
Chan, Jocelyn Li Ting |
| author_sort |
Chan, Jocelyn Li Ting |
| title |
Towards the total synthesis of apicularen A |
| title_short |
Towards the total synthesis of apicularen A |
| title_full |
Towards the total synthesis of apicularen A |
| title_fullStr |
Towards the total synthesis of apicularen A |
| title_full_unstemmed |
Towards the total synthesis of apicularen A |
| title_sort |
towards the total synthesis of apicularen a |
| publishDate |
2010 |
| url |
http://hdl.handle.net/10356/41762 |
| _version_ |
1759855998785290240 |