Towards the total synthesis of apicularen A

• المؤلف الرئيسي: Chan, Jocelyn Li Ting
• مؤلفون آخرون: Loh Teck Peng
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2010
• الموضوعات: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/41762

This thesis involves the synthesis of an intermediate towards Apicularen A utilizing indium-mediated conjugate addition of a thioester derived ketene to a conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential for its bioactivity as a potential anti-cancer agent.