Investigation of new properties and applications of g-quadruplex DNA and I-motif DNA
Some sequences of DNA that possess certain guanine or cytosine-riched stretches are capable of associating into two types of four-stranded DNA structures, namely G-quadruplex and i-motif respectively, which could exist in some biologically important regions of DNA such as the end of chromosomes a...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/42437 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Some sequences of DNA that possess certain guanine or cytosine-riched stretches are
capable of associating into two types of four-stranded DNA structures, namely
G-quadruplex and i-motif respectively, which could exist in some biologically important regions of DNA
such as the end of chromosomes and the regulatory regions of oncogenes. With the aim of
exploring new properties and applications of quadruplex DNA during my graduate studies,
we have investigated the factors that affect the G-quadruplex that could undergo
self-cleavage reactions, and developed certain fluorescence-tagged circular i-motifs to be
used as molecular probes. |
|---|