Study of islet amyloid polypeptide aggregation and its inhibition mechanisms.

• Main Author: Wei, Lei.
• Other Authors: Konstantin Pervushin
• Format: Theses and Dissertations
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/42907
• Institution: Nanyang Technological University

Islet amyloid polypeptide (IAPP), a 37-amino acid polypeptide hormone of calcitonin family, is co-expressed and co-secreted with insulin in pancreatic islet β cells. Abnormal aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils is a hallmark of type 2 diabetes. Determining the molec...