Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis

In this project, the effect of TNFa on the expression of ICAM-1 and (31 integrin (receptor of endothelial VCAM-1) on monocytes (U937 cells) was studied. In addition, an attempt was made to investigate the involvement of SPHK in this TNFa signaling pathway and to identify the mediators involved in th...

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Main Author:	Tuang, Chew Yan.
Other Authors:	School of Mechanical and Aerospace Engineering
Format:	Theses and Dissertations
Published:	2008
Subjects:	DRNTU::Engineering::Mechanical engineering::Bio-mechatronics
Online Access:	http://hdl.handle.net/10356/5313
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Institution:	Nanyang Technological University

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record_format	dspace
spelling	sg-ntu-dr.10356-53132023-03-11T17:14:14Z Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis Tuang, Chew Yan. School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering::Bio-mechatronics In this project, the effect of TNFa on the expression of ICAM-1 and (31 integrin (receptor of endothelial VCAM-1) on monocytes (U937 cells) was studied. In addition, an attempt was made to investigate the involvement of SPHK in this TNFa signaling pathway and to identify the mediators involved in the cascade. It was found that TNFa up-regulated the expression of ICAM-1 and integrin pi on monocytes and SPHK was involved in the signaling cascade. Master of Science (Biomedical Engineering) 2008-09-17T10:47:39Z 2008-09-17T10:47:39Z 2006 2006 Thesis http://hdl.handle.net/10356/5313 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Engineering::Mechanical engineering::Bio-mechatronics
spellingShingle	DRNTU::Engineering::Mechanical engineering::Bio-mechatronics Tuang, Chew Yan. Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis
description	In this project, the effect of TNFa on the expression of ICAM-1 and (31 integrin (receptor of endothelial VCAM-1) on monocytes (U937 cells) was studied. In addition, an attempt was made to investigate the involvement of SPHK in this TNFa signaling pathway and to identify the mediators involved in the cascade. It was found that TNFa up-regulated the expression of ICAM-1 and integrin pi on monocytes and SPHK was involved in the signaling cascade.
author2	School of Mechanical and Aerospace Engineering
author_facet	School of Mechanical and Aerospace Engineering Tuang, Chew Yan.
format	Theses and Dissertations
author	Tuang, Chew Yan.
author_sort	Tuang, Chew Yan.
title	Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis
title_short	Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis
title_full	Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis
title_fullStr	Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis
title_full_unstemmed	Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis
title_sort	role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis
publishDate	2008
url	http://hdl.handle.net/10356/5313
_version_	1761781263118630912

Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis

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