Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis
In this project, the effect of TNFa on the expression of ICAM-1 and (31 integrin (receptor of endothelial VCAM-1) on monocytes (U937 cells) was studied. In addition, an attempt was made to investigate the involvement of SPHK in this TNFa signaling pathway and to identify the mediators involved in th...
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Format: | Theses and Dissertations |
Published: |
2008
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Online Access: | http://hdl.handle.net/10356/5313 |
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Institution: | Nanyang Technological University |