Role of sphingosine kinase in the expression of adhesion molecules on monocytes induced by tumor necrosis factor-alpha : relevance to atherosclerosis

• Main Author: Tuang, Chew Yan.
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Theses and Dissertations
• Published: 2008
• Subjects: DRNTU::Engineering::Mechanical engineering::Bio-mechatronics
• Online Access: http://hdl.handle.net/10356/5313
• Institution: Nanyang Technological University

In this project, the effect of TNFa on the expression of ICAM-1 and (31 integrin (receptor of endothelial VCAM-1) on monocytes (U937 cells) was studied. In addition, an attempt was made to investigate the involvement of SPHK in this TNFa signaling pathway and to identify the mediators involved in th...