The role of growth factor receptor bound protein 2 (GRB2) in gain of function of mutant p53.

• Main Author: Lau, Sok Ting.
• Other Authors: Surajit Bhattacharyya
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology
• Online Access: http://hdl.handle.net/10356/54806
• Institution: Nanyang Technological University

Mutation and inactivation of p53 is almost a universal feature in human cancer. That has made p53 one of the most studied proteins. Several mutant p53 have been shown to have dominant phenotype over wild-type p53. Studies have attributed the ability of mutant p53 to acquire oncogenic properties such...