Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles
Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes to link magnetic micro-beads were explored and established. Using those techniques, we propose a method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloi...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/74927 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes
to link magnetic micro-beads were explored and established. Using those techniques, we propose a
method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloidal
interactions of G-quadruplex DNA-coated magnetic micro-particle chains. By adjusting the concentration
of K+ ions in the bu er solution, we select a suitable concentration of the K+ whereby, the natural
dissociation of the magnetic micro-particle chains is optimal. |
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