Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles

Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles

Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes to link magnetic micro-beads were explored and established. Using those techniques, we propose a method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloi...

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Main Author: Tan, Keith Wei Rong
Other Authors: Phan Anh Tuan
Format: Final Year Project
Language:English
Published: 2018
Subjects:
DRNTU::Science::Biological sciences::Biophysics
Online Access:http://hdl.handle.net/10356/74927
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-749272023-02-28T23:13:10Z Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles Tan, Keith Wei Rong Phan Anh Tuan School of Physical and Mathematical Sciences DRNTU::Science::Biological sciences::Biophysics Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes to link magnetic micro-beads were explored and established. Using those techniques, we propose a method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloidal interactions of G-quadruplex DNA-coated magnetic micro-particle chains. By adjusting the concentration of K+ ions in the bu er solution, we select a suitable concentration of the K+ whereby, the natural dissociation of the magnetic micro-particle chains is optimal. Bachelor of Science in Physics 2018-05-25T01:40:58Z 2018-05-25T01:40:58Z 2018 Final Year Project (FYP) http://hdl.handle.net/10356/74927 en 55 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Biophysics
spellingShingle DRNTU::Science::Biological sciences::Biophysics
Tan, Keith Wei Rong
Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles
description Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes to link magnetic micro-beads were explored and established. Using those techniques, we propose a method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloidal interactions of G-quadruplex DNA-coated magnetic micro-particle chains. By adjusting the concentration of K+ ions in the bu er solution, we select a suitable concentration of the K+ whereby, the natural dissociation of the magnetic micro-particle chains is optimal.
author2 Phan Anh Tuan
author_facet Phan Anh Tuan
Tan, Keith Wei Rong
format Final Year Project
author Tan, Keith Wei Rong
author_sort Tan, Keith Wei Rong
title Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles
title_short Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles
title_full Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles
title_fullStr Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles
title_full_unstemmed Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles
title_sort using colloidal disassembly to determine molecular stability of dna-coated magnetic micro-particles
publishDate 2018
url http://hdl.handle.net/10356/74927
_version_ 1759854377630171136

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