Uncovering the function of CREB regulated transcription coactivator 2 (CRTC2) in rodent brain

• Main Author: Lim, Wei Lee
• Other Authors: Ch’ng Toh Hean
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2018
• Subjects: DRNTU::Science::Biological sciences::Biochemistry; DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/74944
• Institution: Nanyang Technological University

CRTC2 is potent transcriptional coactivator that undergoes robust nucleo-cytoplasmic shuttling to enhance CREB-mediated transcription in multiple cell types. In hepatocytes and pancreatic islet β-cells, CRTC2 responds to both glucose and incretin signals by activating CREB and upregulating the gen...