Uncovering the function of CREB regulated transcription coactivator 2 (CRTC2) in rodent brain

• المؤلف الرئيسي: Lim, Wei Lee
• مؤلفون آخرون: Ch’ng Toh Hean
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2018
• الموضوعات: DRNTU::Science::Biological sciences::Biochemistry; DRNTU::Science::Biological sciences::Molecular biology
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/74944

CRTC2 is potent transcriptional coactivator that undergoes robust nucleo-cytoplasmic shuttling to enhance CREB-mediated transcription in multiple cell types. In hepatocytes and pancreatic islet β-cells, CRTC2 responds to both glucose and incretin signals by activating CREB and upregulating the gen...