Monitoring chaperone aggregation to measure ribosomal stalling

• Main Author: Chan, Tristan Yew Kit
• Other Authors: Choe Young Jun
• Format: Final Year Project
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/78994
• Institution: Nanyang Technological University

Proteostatic disequilibrium, the inability for cellular components to synchronously balance protein synthesis, folding and degradation, has been implicated in various ageing-related diseases, including Alzheimer’s and Parkinson’s disease, which often manifest through protein aggregation, toxicity an...