Binding of dsRNAs by PNAs containing Q, modified Q and 2-thio Uracil monomers

• Main Author: Lina Nur Lyana Abdul Rahim
• Other Authors: Chen Gang
• Format: Final Year Project
• Language: English
• Published: 2019
• Subjects: Science::Chemistry
• Online Access: http://hdl.handle.net/10356/79017
• Institution: Nanyang Technological University

Peptide nucleic acids (PNAs) have been developed as chemical probes and therapeutic ligands in RNA duplex recognition. PNAs bind to ribonucleic acid (RNA) duplexes via complementary Hoogsteen hydrogen bonding to form PNA·RNA2 triplexes. In this study, modifications were made to chemically synthesize...