Insight into enzymatic nitrile reduction : QM/MM study of the catalytic mechanism of QueF nitrile reductase
The NADPH-dependent QueF nitrile reductases catalyze the unprecedented four-electron reduction of nitrile to amine. QueF nitrile reductases can be found in the tRNA biosynthetic pathway of many bacteria and are potential antimicrobial drug targets. QueF enzymes have also attracted great attention as...
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Main Authors: | Ribeiro, António J. M., Yang, Lifeng, Ramos, Maria J., Fernandes, Pedro A., Liang, Zhao-Xun, Hirao, Hajime |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2015
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/79375 http://hdl.handle.net/10220/34457 |
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Institution: | Nanyang Technological University |
Language: | English |
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