RpoN Regulates Virulence Factors of Pseudomonas aeruginosa via Modulating the PqsR Quorum Sensing Regulator

• Main Authors: Cai, Zhao, Liu, Yang, Chen, Yicai, Yam, Joey Kuok Hoong, Chew, Su Chuen, Chua, Song Lin, Wang, Ke, Givskov, Michael, Yang, Liang
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2015
• Subjects: Pseudomonas aeruginosa; Quorum sensing; RpoN; PqsR
• Online Access: https://hdl.handle.net/10356/81047; http://hdl.handle.net/10220/39098
• Institution: Nanyang Technological University

The alternative sigma factor RpoN regulates many cell functions, such as motility, quorum sensing, and virulence in the opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa). P. aeruginosa often evolves rpoN-negative variants during the chronic infection in cystic fibrosis patients. It is un...