The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC i...

Full description

Saved in:
Bibliographic Details
Main Authors: Lu, Xinyi, Sachs, Friedrich, Ramsay, LeeAnn, Jacques, Pierre-Étienne, Göke, Jonathan, Bourque, Guillaume, Ng, Huck-Hui
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2016
Subjects:
Long non-coding RNAs
Pluripotent stem cells
Online Access:https://hdl.handle.net/10356/81803
http://hdl.handle.net/10220/40971
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-81803
record_format dspace
spelling sg-ntu-dr.10356-818032020-03-07T12:18:04Z The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity Lu, Xinyi Sachs, Friedrich Ramsay, LeeAnn Jacques, Pierre-Étienne Göke, Jonathan Bourque, Guillaume Ng, Huck-Hui School of Biological Sciences Long non-coding RNAs Pluripotent stem cells Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs. ASTAR (Agency for Sci., Tech. and Research, S’pore) 2016-07-19T08:07:01Z 2019-12-06T14:40:46Z 2016-07-19T08:07:01Z 2019-12-06T14:40:46Z 2014 Journal Article Lu, X., Sachs, F., Ramsay, L., Jacques, P.-É., Göke, J., Bourque, G., et al. (2014). The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity. Nature Structural & Molecular Biology, 21(4), 423-425. 1545-9993 https://hdl.handle.net/10356/81803 http://hdl.handle.net/10220/40971 10.1038/nsmb.2799 en Nature Structural & Molecular Biology © 2014 Nature America.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Long non-coding RNAs
Pluripotent stem cells
spellingShingle Long non-coding RNAs
Pluripotent stem cells
Lu, Xinyi
Sachs, Friedrich
Ramsay, LeeAnn
Jacques, Pierre-Étienne
Göke, Jonathan
Bourque, Guillaume
Ng, Huck-Hui
The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
description Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Lu, Xinyi
Sachs, Friedrich
Ramsay, LeeAnn
Jacques, Pierre-Étienne
Göke, Jonathan
Bourque, Guillaume
Ng, Huck-Hui
format Article
author Lu, Xinyi
Sachs, Friedrich
Ramsay, LeeAnn
Jacques, Pierre-Étienne
Göke, Jonathan
Bourque, Guillaume
Ng, Huck-Hui
author_sort Lu, Xinyi
title The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
title_short The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
title_full The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
title_fullStr The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
title_full_unstemmed The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
title_sort retrovirus hervh is a long noncoding rna required for human embryonic stem cell identity
publishDate 2016
url https://hdl.handle.net/10356/81803
http://hdl.handle.net/10220/40971
_version_ 1681049721010913280

Similar Items