The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

• Main Authors: Lu, Xinyi, Sachs, Friedrich, Ramsay, LeeAnn, Jacques, Pierre-Étienne, Göke, Jonathan, Bourque, Guillaume, Ng, Huck-Hui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Long non-coding RNAs; Pluripotent stem cells
• Online Access: https://hdl.handle.net/10356/81803; http://hdl.handle.net/10220/40971
• Institution: Nanyang Technological University

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC i...