Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for −1 ribosomal frameshifting stimulation

• Main Authors: Zhong, Zhensheng, Yang, Lixia, Zhang, Haiping, Shi, Jiahao, Vandana, J. Jeya, Lam, Do Thuy Uyen Ha, Olsthoorn, René C. L., Lu, Lanyuan, Chen, Gang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Biophysical chemistry; Molecular conformation
• Online Access: https://hdl.handle.net/10356/83910; http://hdl.handle.net/10220/42835
• Institution: Nanyang Technological University

Minus-one ribosomal frameshifting is a translational recoding mechanism widely utilized by many RNA viruses to generate accurate ratios of structural and catalytic proteins. An RNA pseudoknot structure located in the overlapping region of the gag and pro genes of Simian Retrovirus type 1 (SRV-1) sti...