Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles

Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles

Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle.

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Bibliographic Details
Main Authors: Jiao, Zhiwei, Chee, Kwok Wei, Zhou, Jianrong Steve
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2017
Subjects:
Palladium catalysis
Alkylnitrile
Online Access:https://hdl.handle.net/10356/84965
http://hdl.handle.net/10220/43605
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Institution: Nanyang Technological University
Language: English
Description
Summary:Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle.

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