Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles

• Main Authors: Jiao, Zhiwei, Chee, Kwok Wei, Zhou, Jianrong Steve
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Palladium catalysis; Alkylnitrile
• Online Access: https://hdl.handle.net/10356/84965; http://hdl.handle.net/10220/43605
• Institution: Nanyang Technological University

Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle.