Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles
Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle.
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sg-ntu-dr.10356-849652023-02-28T19:29:53Z Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles Jiao, Zhiwei Chee, Kwok Wei Zhou, Jianrong Steve School of Physical and Mathematical Sciences Palladium catalysis Alkylnitrile Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle. MOE (Min. of Education, S’pore) Accepted version 2017-08-18T01:15:52Z 2019-12-06T15:54:31Z 2017-08-18T01:15:52Z 2019-12-06T15:54:31Z 2016 Journal Article Jiao, Z., Chee, K. W., & Zhou, J. S. (2016). Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles. Journal of the American Chemical Society, 138(50), 16240-16243. 0002-7863 https://hdl.handle.net/10356/84965 http://hdl.handle.net/10220/43605 10.1021/jacs.6b11610 en Journal of the American Chemical Society © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of the American Chemical Society, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/jacs.6b11610]. 5 p. application/pdf |
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Palladium catalysis Alkylnitrile |
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Palladium catalysis Alkylnitrile Jiao, Zhiwei Chee, Kwok Wei Zhou, Jianrong Steve Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles |
| description |
Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Jiao, Zhiwei Chee, Kwok Wei Zhou, Jianrong Steve |
| format |
Article |
| author |
Jiao, Zhiwei Chee, Kwok Wei Zhou, Jianrong Steve |
| author_sort |
Jiao, Zhiwei |
| title |
Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles |
| title_short |
Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles |
| title_full |
Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles |
| title_fullStr |
Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles |
| title_full_unstemmed |
Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles |
| title_sort |
palladium-catalyzed asymmetric α-arylation of alkylnitriles |
| publishDate |
2017 |
| url |
https://hdl.handle.net/10356/84965 http://hdl.handle.net/10220/43605 |
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1759855246962589696 |