Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

• Main Authors: Toh, Desiree-Faye Kaixin, Patil, Kiran M., Chen, Gang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: PNA; Genetics
• Online Access: https://hdl.handle.net/10356/86514; http://hdl.handle.net/10220/44058
• Institution: Nanyang Technological University

RNAs are emerging as important biomarkers and therapeutic targets. Thus, there is great potential in developing chemical probes and therapeutic ligands for the recognition of RNA sequence and structure. Chemically modified Peptide Nucleic Acid (PNA) oligomers have been recently developed that can re...