Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

• المؤلفون الرئيسيون: Toh, Desiree-Faye Kaixin, Patil, Kiran M., Chen, Gang
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: PNA; Genetics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/86514; http://hdl.handle.net/10220/44058

RNAs are emerging as important biomarkers and therapeutic targets. Thus, there is great potential in developing chemical probes and therapeutic ligands for the recognition of RNA sequence and structure. Chemically modified Peptide Nucleic Acid (PNA) oligomers have been recently developed that can re...