Essential role of the flexible linker on the conformational equilibrium of bacterial peroxiredoxin reductase for effective regeneration of peroxiredoxin

• Main Authors: Grüber, Gerhard, Kamariah, Neelagandan, Eisenhaber, Birgit, Eisenhaber, Frank
• 其他作者: School of Computer Science and Engineering
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Antioxidant; Electron Transfer
• 在線閱讀: https://hdl.handle.net/10356/87081; http://hdl.handle.net/10220/44312

Reactive oxygen species (ROS) can damage DNA, proteins, and lipids, so cells have antioxidant systems that regulate ROS. In many bacteria, a dedicated peroxiredoxin reductase, alkyl hydroperoxide reductase subunit F (AhpF), catalyzes the rapid reduction of the redox-active disulfide center of the an...