Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Carboxylic acids are common moieties in medicines. They can be converted to phthalidyl esters as prodrugs. Unfortunately, phthalidyl esters are now mostly prepared in racemic forms. This is not desirable because the two enantiomers of phthalidyl esters likely have different pharmacological effects....

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Yingguo, Chen, Qiao, Mou, Chengli, Pan, Lutai, Duan, Xiaoyong, Chen, Xingkuan, Chen, Hongzhong, Zhao, Yanli, Lu, Yunpeng, Jin, Zhichao, Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2019
Subjects:
Online Access:https://hdl.handle.net/10356/87107
http://hdl.handle.net/10220/49866
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English