Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

• المؤلفون الرئيسيون: Liu, Yingguo, Chen, Qiao, Mou, Chengli, Pan, Lutai, Duan, Xiaoyong, Chen, Xingkuan, Chen, Hongzhong, Zhao, Yanli, Lu, Yunpeng, Jin, Zhichao, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Asymmetric Catalysis; Drug Discovery and Development; Science::Chemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87107; http://hdl.handle.net/10220/49866
• المؤسسة: Nanyang Technological University

Carboxylic acids are common moieties in medicines. They can be converted to phthalidyl esters as prodrugs. Unfortunately, phthalidyl esters are now mostly prepared in racemic forms. This is not desirable because the two enantiomers of phthalidyl esters likely have different pharmacological effects....