Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

• Main Authors: Liu, Yingguo, Chen, Qiao, Mou, Chengli, Pan, Lutai, Duan, Xiaoyong, Chen, Xingkuan, Chen, Hongzhong, Zhao, Yanli, Lu, Yunpeng, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Asymmetric Catalysis; Drug Discovery and Development; Science::Chemistry
• Online Access: https://hdl.handle.net/10356/87107; http://hdl.handle.net/10220/49866
• Institution: Nanyang Technological University

Carboxylic acids are common moieties in medicines. They can be converted to phthalidyl esters as prodrugs. Unfortunately, phthalidyl esters are now mostly prepared in racemic forms. This is not desirable because the two enantiomers of phthalidyl esters likely have different pharmacological effects....