Longitudinal study of cellular and systemic cytokine signatures to define the dynamics of a balanced immune environment during disease manifestation in Zika virus–infected patients

• Main Authors: Lum, Fok-Moon, Lee, Bernett, Lye, David Chien Boon, Tan, Jeslin J. L., Siti N. Amrun, Chia, Po-Ying, Chua, Tze-Kwang, Kam, Yiu-Wing, Yee, Wearn-Xin, Ling, Wei-Ping, Mok, Esther W. H., Chong, Chia-Yin, Leo, Yee-Sin, Ng, Lisa F. P., Lim, Vanessa W. X., Pang, Vincent J. X.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Zika Virus; Patient Cohort; Science::Medicine
• Online Access: https://hdl.handle.net/10356/87188; http://hdl.handle.net/10220/49882
• Institution: Nanyang Technological University

Background: Since its unexpected reemergence, Zika virus (ZIKV) has caused numerous outbreaks globally. This study characterized the host immune responses during ZIKV infection. Methods: Patient samples were collected longitudinally during the acute, convalescence and recovery phases of ZIKV infecti...