Single-molecule force spectroscopy on histone H4 tail-cross-linked chromatin reveals fiber folding

• Main Authors: Kaczmarczyk, Artur, Allahverdi, Abdollah, Brouwer, Thomas B., Nordenskiöld, Lars, Dekker, Nynke H., Van Noort, John
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Chromatin Structure; Chromatin Compaction
• Online Access: https://hdl.handle.net/10356/87233; http://hdl.handle.net/10220/44349
• Institution: Nanyang Technological University

The eukaryotic genome is highly compacted into a protein-DNA complex called chromatin. The cell controls access of transcriptional regulators to chromosomal DNA via several mechanisms that act on chromatin-associated proteins and provide a rich spectrum of epigenetic regulation. Elucidating the mech...