NLRP10 Enhances CD4+ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release

• Main Authors: Vacca, Maurizio, Böhme, Julia, Zambetti, Lia Paola, Khameneh, Hanif Javanmard, Paleja, Bhairav S., Laudisi, Federica, Ho, Adrian W. S., Neo, Kurt, Leong, Keith Weng Kit, Marzuki, Mardiana, Lee, Bernett, Poidinger, Michael, Santambrogio, Laura, Tsenova, Liana, Zolezzi, Francesca, De Libero, Gennaro, Singhal, Amit, Mortellaro, Alessandra
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Mycobacterium Tuberculosis; Dendritic Cells
• Online Access: https://hdl.handle.net/10356/87419; http://hdl.handle.net/10220/44459
• Institution: Nanyang Technological University

NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor for microbial products. Here, we generated a Nlrp10−/− mouse to delineate the role of NLRP10 in the host immune response and found that Nlrp10−/− dendritic cells (DCs)...