LFA-1/ICAM-1 ligation in human T cells promotes Th1 polarization through a GSK3β signaling–dependent notch pathway

• Main Authors: Ong, Seow Theng, Low, Jian Hui, Kottaiswamy, Amuthavalli, Kizhakeyil, Atish, Kumar, Sunil, Panda, Aditya K., Freeley, Michael, Smith, Sinead M., Boehm, Bernhard O., Kelleher, Dermot, Verma, Navin Kumar, Mobashar Hussain Urf Turabe Fazil, Chalasani, Madhavi Latha Somaraju, Praseetha P
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Signaling–Dependent Notch Pathway; Polarization; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/87786; http://hdl.handle.net/10220/46815
• Institution: Nanyang Technological University

In this study, we report that the integrin LFA-1 cross-linking with its ligand ICAM-1 in human PBMCs or CD4+ T cells promotes Th1 polarization by upregulating IFN-γ secretion and T-bet expression. LFA-1 stimulation in PBMCs, CD4+ T cells, or the T cell line HuT78 activates the Notch pathway by nucle...