Evaluation of a Sustained-release Prednisolone Acetate Biodegradable Subconjunctival Implant in a Non-Human Primate Model

• Main Authors: Liu, Yu-Chi, Ng, Anthony Herr Cheun, Ng, Xu Wen, Yan, Peng, Venkatraman, Subbu Subramanian, Mehta, Jodhbir Singh, Wong, Tina Tzee Ling
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Drug Delivery; Subconjunctival
• Online Access: https://hdl.handle.net/10356/88205; http://hdl.handle.net/10220/44578
• Institution: Nanyang Technological University

Purpose: We evaluate the toxicity and plasma toxicokinetic (TK) profile of a biodegradable subconjunctival microrod for sustained prednisolone acetate (PA) release over 12 weeks in a non-human primate model. Methods: The biodegradable copolymer poly(l-lactide-co-ε-caprolactone) (PLC) and 40-wt% PA m...