Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor

• Main Authors: Chung, Hwa Hwa, Sze, Siu Kwan, Woo, Amanda Rui En, Sun, Yang, Sim, Kae Hwan, Dong, Xue Ming, Lin, Valerie Chun-Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Post-translational Modification; Protein Methylation; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88378; http://hdl.handle.net/10220/45806
• Institution: Nanyang Technological University

Progesterone receptor (PR) exists in two isoforms, PRA and PRB, and both contain activation functions AF-1 and AF-2. It is believed that AF-1 is primarily responsible for the ligand-independent activity, whereas AF-2 mediates ligand-dependent PR activation. Although more than a dozen post-translatio...