Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles

Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles

Many 1,3‐azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three‐membered rings is retained in the products. Thus, the cyclopropyl–halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl rad...

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Main Authors: Wu, Xiaojin, Lei, Chuanhu, Yue, Guizhou, Zhou, Jianrong (Steve)
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2018
Subjects:
Heterocycles
Alkyl Halides
Online Access:https://hdl.handle.net/10356/89367
http://hdl.handle.net/10220/44889
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-893672023-02-28T19:24:07Z Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles Wu, Xiaojin Lei, Chuanhu Yue, Guizhou Zhou, Jianrong (Steve) School of Physical and Mathematical Sciences Heterocycles Alkyl Halides Many 1,3‐azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three‐membered rings is retained in the products. Thus, the cyclopropyl–halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl radicals are not involved in the productive pathway. MOE (Min. of Education, S’pore) Accepted version 2018-05-24T04:30:51Z 2019-12-06T17:23:57Z 2018-05-24T04:30:51Z 2019-12-06T17:23:57Z 2015 Journal Article Wu, X., Lei, C., Yue, G., & Zhou, J. (S.) (2015). Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles. Angewandte Chemie International Edition, 54(33), 9601-9605. 1433-7851 https://hdl.handle.net/10356/89367 http://hdl.handle.net/10220/44889 10.1002/anie.201504735 en Angewandte Chemie International Edition © 2015 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/anie.201504735]. 5 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Heterocycles
Alkyl Halides
spellingShingle Heterocycles
Alkyl Halides
Wu, Xiaojin
Lei, Chuanhu
Yue, Guizhou
Zhou, Jianrong (Steve)
Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
description Many 1,3‐azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three‐membered rings is retained in the products. Thus, the cyclopropyl–halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl radicals are not involved in the productive pathway.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Wu, Xiaojin
Lei, Chuanhu
Yue, Guizhou
Zhou, Jianrong (Steve)
format Article
author Wu, Xiaojin
Lei, Chuanhu
Yue, Guizhou
Zhou, Jianrong (Steve)
author_sort Wu, Xiaojin
title Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
title_short Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
title_full Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
title_fullStr Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
title_full_unstemmed Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
title_sort palladium‐catalyzed direct cyclopropylation of heterocycles
publishDate 2018
url https://hdl.handle.net/10356/89367
http://hdl.handle.net/10220/44889
_version_ 1759853984439336960

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