Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles

• Main Authors: Wu, Xiaojin, Lei, Chuanhu, Yue, Guizhou, Zhou, Jianrong (Steve)
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Heterocycles; Alkyl Halides
• Online Access: https://hdl.handle.net/10356/89367; http://hdl.handle.net/10220/44889
• Institution: Nanyang Technological University

Many 1,3‐azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three‐membered rings is retained in the products. Thus, the cyclopropyl–halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl rad...