Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer’s disease with cerebrovascular disease

• Main Authors: Gallart-Palau, Xavier, Lee, Benjamin Sian Teck, Adav, Sunil Shankar, Qian, Jingru, Serra, Aida, Park, Jung Eun, Lai, Mitchell K. P., Chen, Christopher P., Kalaria, Raj N., Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences; Alzheimer’s Disease; Cerebrovascular Disease
• Online Access: https://hdl.handle.net/10356/89979; http://hdl.handle.net/10220/46445
• Institution: Nanyang Technological University

Background: Dementia risk in women is higher than in men, but the molecular neuropathology of this gender difference remains poorly defined. In this study, we used unbiased, discovery-driven quantitative proteomics to assess the molecular basis of gender influences on risk of Alzheimer’s disease wit...