Effects of LNA modification on the stability and structure of DNA G-quadruplex

Effects of LNA modification on the stability and structure of DNA G-quadruplex

Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligo...

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Main Author: Li, Zhe
Other Authors: Phan Anh Tuan
Format: Student Research Poster
Language:English
Published: 2013
Subjects:
DNA
G-quadruplex
Online Access:https://hdl.handle.net/10356/94624
http://hdl.handle.net/10220/9099
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-946242020-09-27T20:29:07Z Effects of LNA modification on the stability and structure of DNA G-quadruplex Li, Zhe Phan Anh Tuan School of Physical and Mathematical Sciences DNA G-quadruplex Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligonucleotide can be prolonged. Knowledge of the LNA modified G-quadruplex’s stability and structure[4-5] can help in drug design. This project uses various biophysical techniques including 1D and 2D NMR (Nuclear Magnetic Resonance), CD (Circular Dichroism) and UV (UltraViolet) absorption spectroscopy to investigate the effect of LNA modifications on a quadruplex-forming human telomeric sequence. [2nd Award] 2013-02-04T02:47:58Z 2019-12-06T18:59:21Z 2013-02-04T02:47:58Z 2019-12-06T18:59:21Z 2011 2011 Student Research Poster Li, Z. (2011, March). Effects of LNA modification on the stability and structure of DNA G-quadruplex. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/94624 http://hdl.handle.net/10220/9099 en © 2011 The Author(s). application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DNA
G-quadruplex
spellingShingle DNA
G-quadruplex
Li, Zhe
Effects of LNA modification on the stability and structure of DNA G-quadruplex
description Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligonucleotide can be prolonged. Knowledge of the LNA modified G-quadruplex’s stability and structure[4-5] can help in drug design. This project uses various biophysical techniques including 1D and 2D NMR (Nuclear Magnetic Resonance), CD (Circular Dichroism) and UV (UltraViolet) absorption spectroscopy to investigate the effect of LNA modifications on a quadruplex-forming human telomeric sequence. [2nd Award]
author2 Phan Anh Tuan
author_facet Phan Anh Tuan
Li, Zhe
format Student Research Poster
author Li, Zhe
author_sort Li, Zhe
title Effects of LNA modification on the stability and structure of DNA G-quadruplex
title_short Effects of LNA modification on the stability and structure of DNA G-quadruplex
title_full Effects of LNA modification on the stability and structure of DNA G-quadruplex
title_fullStr Effects of LNA modification on the stability and structure of DNA G-quadruplex
title_full_unstemmed Effects of LNA modification on the stability and structure of DNA G-quadruplex
title_sort effects of lna modification on the stability and structure of dna g-quadruplex
publishDate 2013
url https://hdl.handle.net/10356/94624
http://hdl.handle.net/10220/9099
_version_ 1681057831256588288

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