Effects of LNA modification on the stability and structure of DNA G-quadruplex

• Main Author: Li, Zhe
• Other Authors: Phan Anh Tuan
• Format: Student Research Poster
• Language: English
• Published: 2013
• Subjects: DNA; G-quadruplex
• Online Access: https://hdl.handle.net/10356/94624; http://hdl.handle.net/10220/9099
• Institution: Nanyang Technological University

Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligo...