Effects of LNA modification on the stability and structure of DNA G-quadruplex
Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligo...
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| Format: | Student Research Poster |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/94624 http://hdl.handle.net/10220/9099 |
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| Institution: | Nanyang Technological University |
| Language: | English |