Copper-catalyzed aerobic aliphatic C–H oxygenation directed by an amidine moiety

• Main Authors: Wang, Yi-Feng, Chen, Hui, Zhu, Xu, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/96019; http://hdl.handle.net/10220/11278
• Institution: Nanyang Technological University

A method for the oxygenation of tertiary C–H bonds of N-alkylamidines and N-(2-alkylaryl)amidines is described that utilizes the CuBr·SMe2/2,2′-bipyridine catalytic system under an O2 atmosphere and provides dihydrooxazoles and 4H-1,3-benzoxazines. The oxygen atom is incorporated from atmospheric mo...