Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevent host invasion of divergent plasmodial species

• Main Authors: Chandramohanadas, Rajesh, Russell, B., Basappa, Liew, K., Yau, Y. H., Chong, A., Min, L., Gunalan, K., Raman, R., Renia, L., Nosten, F., Shochat, S. G., Dao, M., Sasisekharan, R., Suresh, S., Preiser, P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/96464; http://hdl.handle.net/10220/19458
• Institution: Nanyang Technological University

Malaria causes nearly 1 million deaths annually. Recent emergence of multi-drug resistance highlights the need to develop novel therapeutic interventions against human malaria. Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to identify such proteins as target...