Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity

• Main Authors: Chua, Huey Eng, Zhang, Fan, Zheng, Jie, Mishra, Shital Kumar, Bhowmick, Sourav Saha
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/97165; http://hdl.handle.net/10220/25636; http://www.biomedcentral.com/qc/1752-0509/9/S1/S4
• Institution: Nanyang Technological University

The ongoing cancer research has shown that malignant tumour cells have highly disrupted signalling transduction pathways. In cancer cells, signalling pathways are altered to satisfy the demands of continuous proliferation and survival. The changes in signalling pathways supporting uncontrolled cell...