Structural insights into substrate recognition in proton-dependent oligopeptide transporters

• Main Authors: Quistgaard, Esben M., Jong, Agnes Jin Oi, Nordlund, Pär, Löw, Christian, Guettou, Fatma, Trésaugues, Lionel, Moberg, Per, Jegerschöld, Caroline, Zhu, Lin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99088; http://hdl.handle.net/10220/12615
• Institution: Nanyang Technological University

Short-chain peptides are transported across membranes through promiscuous proton-dependent oligopeptide transporters (POTs)—a subfamily of the major facilitator superfamily (MFS). The human POTs, PEPT1 and PEPT2, are also involved in the absorption of various drugs in the gut as well as transport to...