Synthesis of azimic acid using hydroformylation

• Main Authors: Bates, Roderick Wayland, Kasinathan, Sivarajan
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: Science::Chemistry; Piperidine; Alkaloid
• Online Access: https://hdl.handle.net/10356/99815; http://hdl.handle.net/10220/17781
• Institution: Nanyang Technological University

A synthesis of the alkaloid azimic acid has been achieved using double hydroformylation with a single tandem condensation to form the six membered ring. The oxygen substituent was introduced by diastereoselective dihydroxylation, cis to the existing alkyl substituent. The methyl substituent was intr...