Mutually positive regulatory feedback loop between interferons and estrogen receptor-? in mice: Implications for sex bias in autoimmunity

• Main Authors: Panchanathan R., Shen H., Zhang X., Ho S., Choubey D.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: alpha interferon; estrogen; estrogen receptor alpha; gamma interferon; messenger RNA; STAT1 protein; animal cell; animal cell culture; article; autoimmunity; cell stimulation; controlled study; female; gender bias; gene expression regulation; gene function; gene targeting; genetic association; immunoregulation; interferon induction; intracellular signaling; male; mouse; nonhuman; positive feedback; promoter region; protein expression; receptor upregulation; spleen cell; steady state; systemic lupus erythematosus; transcription initiation; transcription regulation; wild type; Animals; Autoimmunity; Cell Line, Tumor; Estradiol; Estrogen Receptor alpha; Feedback, Physiological; Female; Gene Expression Regulation, Neoplastic; Interferons; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; Sex Characteristics; Signal Transduction; STAT1 Transcription Factor; Transcription, Genetic; Murinae; Mus
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161809
• Institution: National University of Singapore

10.1371/journal.pone.0010868