Changes in the folding landscape of the WW domain provide a molecular mechanism for an inherited genetic syndrome

• Main Authors: Pucheta-Martinez, E, D'Amelio, N, Lelli, M, Martinez-Torrecuadrada, J.L, Sudol, M, Saladino, G, Gervasio, F.L
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: carrier protein; DNA binding protein; messenger RNA; nuclear protein; PQBP1 protein, human; protein binding; WBP11 protein, human; beta sheet; cerebral palsy; chemistry; genetics; human; intellectual impairment; molecular dynamics; nuclear magnetic resonance; pathology; point mutation; protein folding; WW domain; X linked mental retardation; Carrier Proteins; Cerebral Palsy; DNA-Binding Proteins; Humans; Intellectual Disability; Mental Retardation, X-Linked; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Point Mutation; Protein Binding; Protein Conformation, beta-Strand; Protein Folding; RNA, Messenger; WW Domains
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174000
• Institution: National University of Singapore

10.1038/srep30293