Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

10.1038/s41598-018-30686-1

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Main Authors:	Subhash, V.V, Yeo, M.S, Wang, L, Tan, S.H, Wong, F.Y, Thuya, W.L, Tan, W.L, Peethala, P.C, Soe, M.Y, Tan, D.S.P, Padmanabhan, N, Baloglu, E, Shacham, S, Tan, P, Koeffler, H.P, Yong, W.P
Other Authors:	PHARMACY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	antineoplastic agent hydrazine derivative protein p53 selinexor triazole derivative adult animal apoptosis cell cycle cell nucleus cell proliferation drug effect drug screening female human male metabolism mouse nucleocytoplasmic transport pathology stomach tumor tumor cell line Active Transport, Cell Nucleus Adult Animals Antineoplastic Agents Apoptosis Cell Cycle Cell Line, Tumor Cell Nucleus Cell Proliferation Female Humans Hydrazines Male Mice Stomach Neoplasms Triazoles Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174208
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1742082024-04-24T05:48:35Z Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor Subhash, V.V Yeo, M.S Wang, L Tan, S.H Wong, F.Y Thuya, W.L Tan, W.L Peethala, P.C Soe, M.Y Tan, D.S.P Padmanabhan, N Baloglu, E Shacham, S Tan, P Koeffler, H.P Yong, W.P PHARMACY CANCER SCIENCE INSTITUTE OF SINGAPORE DUKE-NUS MEDICAL SCHOOL PHYSIOLOGY MEDICINE antineoplastic agent hydrazine derivative protein p53 selinexor triazole derivative adult animal apoptosis cell cycle cell nucleus cell proliferation drug effect drug screening female human male metabolism mouse nucleocytoplasmic transport pathology stomach tumor tumor cell line Active Transport, Cell Nucleus Adult Animals Antineoplastic Agents Apoptosis Cell Cycle Cell Line, Tumor Cell Nucleus Cell Proliferation Female Humans Hydrazines Male Mice Stomach Neoplasms Triazoles Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays 10.1038/s41598-018-30686-1 Scientific Reports 8 1 12248 2020-09-04T01:46:28Z 2020-09-04T01:46:28Z 2018 Article Subhash, V.V, Yeo, M.S, Wang, L, Tan, S.H, Wong, F.Y, Thuya, W.L, Tan, W.L, Peethala, P.C, Soe, M.Y, Tan, D.S.P, Padmanabhan, N, Baloglu, E, Shacham, S, Tan, P, Koeffler, H.P, Yong, W.P (2018). Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor. Scientific Reports 8 (1) : 12248. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-30686-1 2045-2322 https://scholarbank.nus.edu.sg/handle/10635/174208 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antineoplastic agent hydrazine derivative protein p53 selinexor triazole derivative adult animal apoptosis cell cycle cell nucleus cell proliferation drug effect drug screening female human male metabolism mouse nucleocytoplasmic transport pathology stomach tumor tumor cell line Active Transport, Cell Nucleus Adult Animals Antineoplastic Agents Apoptosis Cell Cycle Cell Line, Tumor Cell Nucleus Cell Proliferation Female Humans Hydrazines Male Mice Stomach Neoplasms Triazoles Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays
spellingShingle	antineoplastic agent hydrazine derivative protein p53 selinexor triazole derivative adult animal apoptosis cell cycle cell nucleus cell proliferation drug effect drug screening female human male metabolism mouse nucleocytoplasmic transport pathology stomach tumor tumor cell line Active Transport, Cell Nucleus Adult Animals Antineoplastic Agents Apoptosis Cell Cycle Cell Line, Tumor Cell Nucleus Cell Proliferation Female Humans Hydrazines Male Mice Stomach Neoplasms Triazoles Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays Subhash, V.V Yeo, M.S Wang, L Tan, S.H Wong, F.Y Thuya, W.L Tan, W.L Peethala, P.C Soe, M.Y Tan, D.S.P Padmanabhan, N Baloglu, E Shacham, S Tan, P Koeffler, H.P Yong, W.P Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
description	10.1038/s41598-018-30686-1
author2	PHARMACY
author_facet	PHARMACY Subhash, V.V Yeo, M.S Wang, L Tan, S.H Wong, F.Y Thuya, W.L Tan, W.L Peethala, P.C Soe, M.Y Tan, D.S.P Padmanabhan, N Baloglu, E Shacham, S Tan, P Koeffler, H.P Yong, W.P
format	Article
author	Subhash, V.V Yeo, M.S Wang, L Tan, S.H Wong, F.Y Thuya, W.L Tan, W.L Peethala, P.C Soe, M.Y Tan, D.S.P Padmanabhan, N Baloglu, E Shacham, S Tan, P Koeffler, H.P Yong, W.P
author_sort	Subhash, V.V
title	Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
title_short	Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
title_full	Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
title_fullStr	Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
title_full_unstemmed	Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
title_sort	anti-tumor efficacy of selinexor (kpt-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174208
_version_	1800914223234023424

Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

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