YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

10.1186/s12974-017-0866-x

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Main Authors:	Li, Z.-Y, Chung, Y.H, Shin, E.-J, Dang, D.-K, Jeong, J.H, Ko, S.K, Nah, S.-Y, Baik, T.G, Jhoo, J.H, Ong, W.-Y, Nabeshima, T, Kim, H.-C
Other Authors:	ANATOMY
Format:	Article
Published:	2020
Subjects:	1 alkyl 2 acetylglycerophosphocholine esterase 1 alkyl 2 acetylglycerophosphocholine esterase 1 amyloid beta protein[1-42] amyloid precursor protein bilobalide cyclooxygenase 2 Ginkgo biloba extract ginkgolide A ginkgolide B ginkgolide C isorhamnetin kaempferol meloxicam presenilin 1 quercetin reactive oxygen metabolite terpene thrombocyte activating factor receptor unclassified drug yy 1224 amyloid beta protein amyloid beta-protein (1-42) lactone peptide fragment plant extract trilactone animal cell animal experiment animal model animal tissue antiinflammatory activity antioxidant activity Article controlled study COX 2 gene down regulation enzyme inhibition gene expression regulation knockout mouse learning disorder memory disorder microglia mouse nerve cell stimulation neuroprotection neurotropism nonhuman PAF acetylhydrolase 1 gene pilot study platelet activating factor receptor gene protein expression protein localization retreatment transgenic mouse upregulation Alzheimer disease animal antagonists and inhibitors biosynthesis degenerative disease gene expression genetics Ginkgo biloba isolation and purification metabolism Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Cyclooxygenase 2 Gene Expression Lactones Mice Mice, Knockout Mice, Transgenic Neurodegenerative Diseases Peptide Fragments Plant Extracts Presenilin-1 Reactive Oxygen Species Terpenes
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179510
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1795102024-04-08T14:38:48Z YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2 Li, Z.-Y Chung, Y.H Shin, E.-J Dang, D.-K Jeong, J.H Ko, S.K Nah, S.-Y Baik, T.G Jhoo, J.H Ong, W.-Y Nabeshima, T Kim, H.-C ANATOMY 1 alkyl 2 acetylglycerophosphocholine esterase 1 alkyl 2 acetylglycerophosphocholine esterase 1 amyloid beta protein[1-42] amyloid precursor protein bilobalide cyclooxygenase 2 Ginkgo biloba extract ginkgolide A ginkgolide B ginkgolide C isorhamnetin kaempferol meloxicam presenilin 1 quercetin reactive oxygen metabolite terpene thrombocyte activating factor receptor unclassified drug yy 1224 amyloid beta protein amyloid beta-protein (1-42) amyloid precursor protein cyclooxygenase 2 lactone peptide fragment plant extract presenilin 1 reactive oxygen metabolite terpene trilactone animal cell animal experiment animal model animal tissue antiinflammatory activity antioxidant activity Article controlled study COX 2 gene down regulation enzyme inhibition gene expression regulation knockout mouse learning disorder memory disorder microglia mouse nerve cell stimulation neuroprotection neurotropism nonhuman PAF acetylhydrolase 1 gene pilot study platelet activating factor receptor gene protein expression protein localization retreatment transgenic mouse upregulation Alzheimer disease animal antagonists and inhibitors biosynthesis degenerative disease gene expression genetics Ginkgo biloba isolation and purification metabolism Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Cyclooxygenase 2 Gene Expression Ginkgo biloba Lactones Mice Mice, Knockout Mice, Transgenic Neurodegenerative Diseases Peptide Fragments Plant Extracts Presenilin-1 Reactive Oxygen Species Terpenes 10.1186/s12974-017-0866-x Journal of Neuroinflammation 14 1 94 2020-10-23T04:49:05Z 2020-10-23T04:49:05Z 2017 Article Li, Z.-Y, Chung, Y.H, Shin, E.-J, Dang, D.-K, Jeong, J.H, Ko, S.K, Nah, S.-Y, Baik, T.G, Jhoo, J.H, Ong, W.-Y, Nabeshima, T, Kim, H.-C (2017). YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2. Journal of Neuroinflammation 14 (1) : 94. ScholarBank@NUS Repository. https://doi.org/10.1186/s12974-017-0866-x 17422094 https://scholarbank.nus.edu.sg/handle/10635/179510 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	1 alkyl 2 acetylglycerophosphocholine esterase 1 alkyl 2 acetylglycerophosphocholine esterase 1 amyloid beta protein[1-42] amyloid precursor protein bilobalide cyclooxygenase 2 Ginkgo biloba extract ginkgolide A ginkgolide B ginkgolide C isorhamnetin kaempferol meloxicam presenilin 1 quercetin reactive oxygen metabolite terpene thrombocyte activating factor receptor unclassified drug yy 1224 amyloid beta protein amyloid beta-protein (1-42) amyloid precursor protein cyclooxygenase 2 lactone peptide fragment plant extract presenilin 1 reactive oxygen metabolite terpene trilactone animal cell animal experiment animal model animal tissue antiinflammatory activity antioxidant activity Article controlled study COX 2 gene down regulation enzyme inhibition gene expression regulation knockout mouse learning disorder memory disorder microglia mouse nerve cell stimulation neuroprotection neurotropism nonhuman PAF acetylhydrolase 1 gene pilot study platelet activating factor receptor gene protein expression protein localization retreatment transgenic mouse upregulation Alzheimer disease animal antagonists and inhibitors biosynthesis degenerative disease gene expression genetics Ginkgo biloba isolation and purification metabolism Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Cyclooxygenase 2 Gene Expression Ginkgo biloba Lactones Mice Mice, Knockout Mice, Transgenic Neurodegenerative Diseases Peptide Fragments Plant Extracts Presenilin-1 Reactive Oxygen Species Terpenes
spellingShingle	1 alkyl 2 acetylglycerophosphocholine esterase 1 alkyl 2 acetylglycerophosphocholine esterase 1 amyloid beta protein[1-42] amyloid precursor protein bilobalide cyclooxygenase 2 Ginkgo biloba extract ginkgolide A ginkgolide B ginkgolide C isorhamnetin kaempferol meloxicam presenilin 1 quercetin reactive oxygen metabolite terpene thrombocyte activating factor receptor unclassified drug yy 1224 amyloid beta protein amyloid beta-protein (1-42) amyloid precursor protein cyclooxygenase 2 lactone peptide fragment plant extract presenilin 1 reactive oxygen metabolite terpene trilactone animal cell animal experiment animal model animal tissue antiinflammatory activity antioxidant activity Article controlled study COX 2 gene down regulation enzyme inhibition gene expression regulation knockout mouse learning disorder memory disorder microglia mouse nerve cell stimulation neuroprotection neurotropism nonhuman PAF acetylhydrolase 1 gene pilot study platelet activating factor receptor gene protein expression protein localization retreatment transgenic mouse upregulation Alzheimer disease animal antagonists and inhibitors biosynthesis degenerative disease gene expression genetics Ginkgo biloba isolation and purification metabolism Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Cyclooxygenase 2 Gene Expression Ginkgo biloba Lactones Mice Mice, Knockout Mice, Transgenic Neurodegenerative Diseases Peptide Fragments Plant Extracts Presenilin-1 Reactive Oxygen Species Terpenes Li, Z.-Y Chung, Y.H Shin, E.-J Dang, D.-K Jeong, J.H Ko, S.K Nah, S.-Y Baik, T.G Jhoo, J.H Ong, W.-Y Nabeshima, T Kim, H.-C YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2
description	10.1186/s12974-017-0866-x
author2	ANATOMY
author_facet	ANATOMY Li, Z.-Y Chung, Y.H Shin, E.-J Dang, D.-K Jeong, J.H Ko, S.K Nah, S.-Y Baik, T.G Jhoo, J.H Ong, W.-Y Nabeshima, T Kim, H.-C
format	Article
author	Li, Z.-Y Chung, Y.H Shin, E.-J Dang, D.-K Jeong, J.H Ko, S.K Nah, S.-Y Baik, T.G Jhoo, J.H Ong, W.-Y Nabeshima, T Kim, H.-C
author_sort	Li, Z.-Y
title	YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2
title_short	YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2
title_full	YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2
title_fullStr	YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2
title_full_unstemmed	YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2
title_sort	yy-1224, a terpene trilactone-strengthened ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of app and ps1 via inhibition of cyclooxygenase-2
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179510
_version_	1800914554505396224

YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

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