YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

10.1186/s12974-017-0866-x

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Bibliographic Details
Main Authors:	Li, Z.-Y, Chung, Y.H, Shin, E.-J, Dang, D.-K, Jeong, J.H, Ko, S.K, Nah, S.-Y, Baik, T.G, Jhoo, J.H, Ong, W.-Y, Nabeshima, T, Kim, H.-C
Other Authors:	ANATOMY
Format:	Article
Published:	2020
Subjects:	1 alkyl 2 acetylglycerophosphocholine esterase 1 alkyl 2 acetylglycerophosphocholine esterase 1 amyloid beta protein[1-42] amyloid precursor protein bilobalide cyclooxygenase 2 Ginkgo biloba extract ginkgolide A ginkgolide B ginkgolide C isorhamnetin kaempferol meloxicam presenilin 1 quercetin reactive oxygen metabolite terpene thrombocyte activating factor receptor unclassified drug yy 1224 amyloid beta protein amyloid beta-protein (1-42) lactone peptide fragment plant extract trilactone animal cell animal experiment animal model animal tissue antiinflammatory activity antioxidant activity Article controlled study COX 2 gene down regulation enzyme inhibition gene expression regulation knockout mouse learning disorder memory disorder microglia mouse nerve cell stimulation neuroprotection neurotropism nonhuman PAF acetylhydrolase 1 gene pilot study platelet activating factor receptor gene protein expression protein localization retreatment transgenic mouse upregulation Alzheimer disease animal antagonists and inhibitors biosynthesis degenerative disease gene expression genetics Ginkgo biloba isolation and purification metabolism Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Cyclooxygenase 2 Gene Expression Lactones Mice Mice, Knockout Mice, Transgenic Neurodegenerative Diseases Peptide Fragments Plant Extracts Presenilin-1 Reactive Oxygen Species Terpenes
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179510
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Institution:	National University of Singapore

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